Generally, there are no reported adverse effects with fluticasone in pregnancy 6. Subcutaneous fluticasone propionate has been shown to produce teratogenic effects in rats though oral administration does not 9 Label. Fluticasone propionate is not carcinogenic, mutagenic, or clastogenic, nor did it affect fertility in animal studies 10 Label. Hover over products below to view reaction partnersįluticasone propionate's use in specific populations has not been well studied 10. Fluticasone propionate is hydrolysed at the FIVE-S-fluoromethyl carbothioate group, forming an inactive metabolite 9, 3 Label. Metabolismįluticasone propionate is cleared from hepatic metabolism by cytochrome P450 3A4 10, 4 Label. Topical fluticasone propionate is only 91% protein bound in serum however 9. Protein bindingįluticasone propionate is 99% protein bound in serum 10. A study of 24 healthy Caucasian males showed a volume of distribution at steady state of 577L following intravenous administration 1. The volume of distribution of intravenous fluticasone propionate is 4.2L/kg 10 Label. A study of 24 healthy Caucasian males showed an inhaled bioavailability of 9.0% 1. Topical absorption of fluticasone propionate is very low but can change depending on a number of factors including integrity of the skin and the presence of inflammation or disease 9. Intranasal exposure results in the majority of the dose being swallowed 3. Intranasal bioavailability of fluticasone propionate is <2%, and oral bioavailability is <1% 10 Label.
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